Researchers have learned how cocaine becomes addictive and changes the brain. The results of the study may help develop new ways of treating cocaine addiction.
The researchers at Mount Sinai School of Medicine learned that the two main neurons (D1 and D2) in the nucleus accumbens region of the brain exert opposite effects on cocaine reward.
“The data suggest a model whereby chronic exposure to cocaine results in an inbalance in activity in the two nucleus accumbens neurons: increased activity in D1 neurons combined with decreased activity in D2 neurons,” said Mary Kay Lobo, PhD, lead study researcher.
The study was done using optogenetics, which controls neuronal activity in rodents.
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