To swear off making mistakes is very easy. All you have to do is swear off having ideas.
Leo Burnett
Alcohol use disorders are influenced by multiple genetic, environmental and behavioral factors, which makes it difficult to find individual genetic markers to help identify people at risk of developing them. A new study examined how a person’s level of response to alcohol, which is closely connected to the development of alcohol use disorders, is related to “gene sets” rather than individual genes. The study shows that glutamate receptor signaling genes that allow brain cells to respond to chemicals, and then communicate that response, are involved in a person’s level of response to alcohol.
“Alcohol dependence is a very complex disorder<’ said Geoff Joslyn, senior scientist at the Ernest Gallo Clinic and Research Center and author of the study.
“We know that inherited genes account for about half of a person’s risk of becoming alcohol dependent but this genetic risk is spread across many genes. To simplify the genetic risk, we took advantage of clinical and epidemiological studies that have shown that a person’s innate response to alcohol, that is people who must drink more than the average person to become drunk, are at a greater risk of becoming alcohol dependent. We studied this alcohol response because we think it is a sub-component of alcohol dependence and is much less genetically complex.”
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